Engineering of Anti-CD133 Trispecific Molecule Capable of Inducing NK Expansion and Driving Antibody-Dependent Cell-Mediated Cytotoxicity

PURPOSE: The selective elimination of cancer stem cells (CSCs) in tumor patients is a crucial goal because CSCs cause drug refractory relapse. To improve the current conventional bispecific immune-engager platform, a 16133 bispecific natural killer (NK) cell engager (BiKE), consisting of scFvs bindi...

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Detalles Bibliográficos
Autores principales: Schmohl, Jörg U., Felices, Martin, Oh, Felix, Lenvik, Alexander J., Lebeau, Aaron M., Panyam, Jayanth, Miller, Jeffrey S., Vallera, Daniel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Cancer Association 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654165/
https://www.ncbi.nlm.nih.gov/pubmed/28231426
http://dx.doi.org/10.4143/crt.2016.491

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654165/
https://www.ncbi.nlm.nih.gov/pubmed/28231426
http://dx.doi.org/10.4143/crt.2016.491

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