Hippocampal neurophysiology is modified by a disease-associated C-terminal fragment of tau protein

The accumulation of cleaved tau fragments in the brain is associated with several tauopathies. For this reason, we recently developed a transgenic mouse that selectively accumulates a C-Terminal 35 kDa human tau fragment (Tau35). These animals develop progressive motor and spatial memory impairment,...

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Detalles Bibliográficos
Autores principales: Tamagnini, Francesco, Walsh, Darren A., Brown, Jon T., Bondulich, Marie K., Hanger, Diane P., Randall, Andrew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654728/
https://www.ncbi.nlm.nih.gov/pubmed/28917666
http://dx.doi.org/10.1016/j.neurobiolaging.2017.07.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654728/
https://www.ncbi.nlm.nih.gov/pubmed/28917666
http://dx.doi.org/10.1016/j.neurobiolaging.2017.07.005

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