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Hyperlipidemia-induced cholesterol crystal production by endothelial cells promotes atherogenesis
Endothelial cells (EC) play a key role in atherosclerosis. Although EC are in constant contact with low density lipoproteins (LDL), how EC process LDL and whether this influences atherogenesis, is unclear. Here we show that EC take up and metabolize LDL, and when overburdened with intracellular chol...
Autores principales: | Baumer, Yvonne, McCurdy, Sara, Weatherby, Tina M., Mehta, Nehal N., Halbherr, Stefan, Halbherr, Pascal, Yamazaki, Noboru, Boisvert, William A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654750/ https://www.ncbi.nlm.nih.gov/pubmed/29066718 http://dx.doi.org/10.1038/s41467-017-01186-z |
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