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Structural basis for the bacterial membrane insertion of dermcidin peptide, DCD-1L

Human dermcidin (DCD) is an antimicrobial peptide secreted constitutively by sweat glands. The anionic derivative, DCD-1L, comprises of the N-terminal 47 residues of DCD and one additional leucine residue. A previous NMR structure of DCD-1L in 50% TFE showed a partial helical conformation, and its c...

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Detalles Bibliográficos
Autores principales: Nguyen, Van Sang, Tan, Kang Wei, Ramesh, Karthik, Chew, Fook Tim, Mok, Yu Keung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654962/
https://www.ncbi.nlm.nih.gov/pubmed/29066724
http://dx.doi.org/10.1038/s41598-017-13600-z