Spatial constraints govern competition of mutant clones in human epidermis

Deep sequencing can detect somatic DNA mutations in tissues permitting inference of clonal relationships. This has been applied to human epidermis, where sun exposure leads to the accumulation of mutations and an increased risk of skin cancer. However, previous studies have yielded conflicting concl...

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Detalles Bibliográficos
Autores principales: Lynch, M. D., Lynch, C. N. S., Craythorne, E., Liakath-Ali, K., Mallipeddi, R., Barker, J. N., Watt, F. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654977/
https://www.ncbi.nlm.nih.gov/pubmed/29066762
http://dx.doi.org/10.1038/s41467-017-00993-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654977/
https://www.ncbi.nlm.nih.gov/pubmed/29066762
http://dx.doi.org/10.1038/s41467-017-00993-8

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