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Activation of STAT3 integrates common profibrotic pathways to promote fibroblast activation and tissue fibrosis
Signal transducer and activator of transcription 3 (STAT3) is phosphorylated by various kinases, several of which have been implicated in aberrant fibroblast activation in fibrotic diseases including systemic sclerosis (SSc). Here we show that profibrotic signals converge on STAT3 and that STAT3 may...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654983/ https://www.ncbi.nlm.nih.gov/pubmed/29066712 http://dx.doi.org/10.1038/s41467-017-01236-6 |