Activation of STAT3 integrates common profibrotic pathways to promote fibroblast activation and tissue fibrosis

Signal transducer and activator of transcription 3 (STAT3) is phosphorylated by various kinases, several of which have been implicated in aberrant fibroblast activation in fibrotic diseases including systemic sclerosis (SSc). Here we show that profibrotic signals converge on STAT3 and that STAT3 may...

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Detalles Bibliográficos
Autores principales: Chakraborty, Debomita, Šumová, Barbora, Mallano, Tatjana, Chen, Chih-Wei, Distler, Alfiya, Bergmann, Christina, Ludolph, Ingo, Horch, Raymund E., Gelse, Kolja, Ramming, Andreas, Distler, Oliver, Schett, Georg, Šenolt, Ladislav, Distler, Jörg H. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654983/
https://www.ncbi.nlm.nih.gov/pubmed/29066712
http://dx.doi.org/10.1038/s41467-017-01236-6

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