Many si/shRNAs can kill cancer cells by targeting multiple survival genes through an off-target mechanism

Over 80% of multiple-tested siRNAs and shRNAs targeting CD95 or CD95 ligand (CD95L) induce a form of cell death characterized by simultaneous activation of multiple cell death pathways preferentially killing transformed and cancer stem cells. We now show these si/shRNAs kill cancer cells through can...

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Detalles Bibliográficos
Autores principales: Putzbach, William, Gao, Quan Q, Patel, Monal, van Dongen, Stijn, Haluck-Kangas, Ashley, Sarshad, Aishe A, Bartom, Elizabeth T, Kim, Kwang-Youn A, Scholtens, Denise M, Hafner, Markus, Zhao, Jonathan C, Murmann, Andrea E, Peter, Marcus E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655136/
https://www.ncbi.nlm.nih.gov/pubmed/29063830
http://dx.doi.org/10.7554/eLife.29702

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655136/
https://www.ncbi.nlm.nih.gov/pubmed/29063830
http://dx.doi.org/10.7554/eLife.29702

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