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Allosteric fine-tuning of the conformational equilibrium poises the chaperone BiP for post-translational regulation

BiP is the only Hsp70 chaperone in the endoplasmic reticulum (ER) and similar to other Hsp70s, its activity relies on nucleotide- and substrate-controllable docking and undocking of its nucleotide-binding domain (NBD) and substrate-binding domain (SBD). However, little is known of specific features...

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Detalles Bibliográficos
Autores principales: Wieteska, Lukasz, Shahidi, Saeid, Zhuravleva, Anastasia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655141/
https://www.ncbi.nlm.nih.gov/pubmed/29064369
http://dx.doi.org/10.7554/eLife.29430