Glypican-3 induces oncogenicity by preventing IGF-1R degradation, a process that can be blocked by Grb10

Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and is a major cause of cancer-related death worldwide. Previously, we demonstrated that glypican-3 (GPC3) is highly expressed in HCC, and that GPC3 induces oncogenicity and promotes the growth of cancer cells through IGF-1 r...

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Detalles Bibliográficos
Autores principales: Cheng, Wei, Huang, Po-Chun, Chao, Hsiao-Mei, Jeng, Yung-Ming, Hsu, Hey-Chi, Pan, Hung-Wei, Hwu, Wuh-Liang, Lee, Yu-May
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655209/
https://www.ncbi.nlm.nih.gov/pubmed/29113314
http://dx.doi.org/10.18632/oncotarget.19035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655209/
https://www.ncbi.nlm.nih.gov/pubmed/29113314
http://dx.doi.org/10.18632/oncotarget.19035

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