Radiation alters PD-L1/NKG2D ligand levels in lung cancer cells and leads to immune escape from NK cell cytotoxicity via IL-6-MEK/Erk signaling pathway

We investigated whether radiation influences the susceptibility of non-small cell lung cancer (NSCLC) cells to NK cell mediated cytotoxicity. We found radiation treatment increased expression of programmed cell death ligand 1 (PD-L1), but decreased NK group 2, member D (NKG2D) ligand expressions in...

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Detalles Bibliográficos
Autores principales: Shen, Ming Jing, Xu, Li Jun, Yang, Li, Tsai, Ying, Keng, Peter C., Chen, Yongbing, Lee, Soo Ok, Chen, Yuhchyau
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655216/
https://www.ncbi.nlm.nih.gov/pubmed/29113321
http://dx.doi.org/10.18632/oncotarget.19193

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655216/
https://www.ncbi.nlm.nih.gov/pubmed/29113321
http://dx.doi.org/10.18632/oncotarget.19193

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