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Radiation alters PD-L1/NKG2D ligand levels in lung cancer cells and leads to immune escape from NK cell cytotoxicity via IL-6-MEK/Erk signaling pathway
We investigated whether radiation influences the susceptibility of non-small cell lung cancer (NSCLC) cells to NK cell mediated cytotoxicity. We found radiation treatment increased expression of programmed cell death ligand 1 (PD-L1), but decreased NK group 2, member D (NKG2D) ligand expressions in...
Autores principales: | Shen, Ming Jing, Xu, Li Jun, Yang, Li, Tsai, Ying, Keng, Peter C., Chen, Yongbing, Lee, Soo Ok, Chen, Yuhchyau |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655216/ https://www.ncbi.nlm.nih.gov/pubmed/29113321 http://dx.doi.org/10.18632/oncotarget.19193 |
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