Unfolded protein response signaling impacts macrophage polarity to modulate breast cancer cell clearance and melanoma immune checkpoint therapy responsiveness

The unfolded protein response (UPR) is a stress pathway controlled by GRP78 to mediate IRE1, PERK, and ATF6 signaling. We show that targeting GRP78, IRE1, and PERK differentially regulates macrophage polarization. Specifically, PERK targeting enhanced macrophage proliferation and macrophage-mediated...

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Detalles Bibliográficos
Autores principales: Soto-Pantoja, David R., Wilson, Adam S., Clear, Kenysha YJ., Westwood, Brian, Triozzi, Pierre L., Cook, Katherine L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655219/
https://www.ncbi.nlm.nih.gov/pubmed/29113324
http://dx.doi.org/10.18632/oncotarget.19849

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655219/
https://www.ncbi.nlm.nih.gov/pubmed/29113324
http://dx.doi.org/10.18632/oncotarget.19849

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