Combined targeting of Raf and Mek synergistically inhibits tumorigenesis in triple negative breast cancer model systems

Aberrant Ras-MAPK signaling from receptor tyrosine kinases (RTKs), including epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor-2 (HER2), is a hallmark of triple negative breast cancer (TNBC); thus providing rationale for targeting the Ras-MAPK pathway. Components of...

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Detalles Bibliográficos
Autores principales: Nagaria, Teddy S., Shi, Changnian, Leduc, Charles, Hoskin, Victoria, Sikdar, Soma, Sangrar, Waheed, Greer, Peter A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655240/
https://www.ncbi.nlm.nih.gov/pubmed/29113345
http://dx.doi.org/10.18632/oncotarget.20534

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655240/
https://www.ncbi.nlm.nih.gov/pubmed/29113345
http://dx.doi.org/10.18632/oncotarget.20534

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