Establishment of a novel hepatocyte model that expresses four cytochrome P450 genes stably via mammalian-derived artificial chromosome for pharmacokinetics and toxicity studies

The utility of HepG2 cells to assess drug metabolism and toxicity induced by chemical compounds is hampered by their low cytochrome P450 (CYP) activities. To overcome this limitation, we established HepG2 cell lines expressing major CYP enzymes involved in drug metabolism (CYP2C9, CYP2C19, CYP2D6, a...

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Detalles Bibliográficos
Autores principales: Satoh, Daisuke, Iwado, Satoru, Abe, Satoshi, Kazuki, Kanako, Wakuri, Shinobu, Oshimura, Mitsuo, Kazuki, Yasuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655360/
https://www.ncbi.nlm.nih.gov/pubmed/29065189
http://dx.doi.org/10.1371/journal.pone.0187072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655360/
https://www.ncbi.nlm.nih.gov/pubmed/29065189
http://dx.doi.org/10.1371/journal.pone.0187072

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