Nicotinamide-based diamides derivatives as potential cytotoxic agents: synthesis and biological evaluation

A series of diamides derivatives containing nicotinamide unit were designed, synthesized and evaluated for their potential cytotoxic activities against human cancer cell lines. All the synthesized compounds were characterized using spectroscopic methods mainly including (1)H NMR, (13)C NMR and MS. T...

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Detalles Bibliográficos
Autores principales: Peng, Min, Shi, Liqiao, Ke, Shaoyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655388/
https://www.ncbi.nlm.nih.gov/pubmed/29086880
http://dx.doi.org/10.1186/s13065-017-0338-5
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author Peng, Min
Shi, Liqiao
Ke, Shaoyong
author_facet Peng, Min
Shi, Liqiao
Ke, Shaoyong
author_sort Peng, Min
collection PubMed
description A series of diamides derivatives containing nicotinamide unit were designed, synthesized and evaluated for their potential cytotoxic activities against human cancer cell lines. All the synthesized compounds were characterized using spectroscopic methods mainly including (1)H NMR, (13)C NMR and MS. The bio-evaluation results indicated that some of the obtained compounds (such as 4d, 4h, 4i) exhibited good to moderate cytotoxic effects on lung cancer cell lines (NCI-H460, A549, and NCI-H1975), especially, compound 4d exhibited the highly potential inhibitory activities against NCI-H460 cell line with the IC(50) values of 4.07 ± 1.30 μg/mL, which might be developed as novel lead compounds for potential cytotoxic agents.
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spelling pubmed-56553882017-11-06 Nicotinamide-based diamides derivatives as potential cytotoxic agents: synthesis and biological evaluation Peng, Min Shi, Liqiao Ke, Shaoyong Chem Cent J Research Article A series of diamides derivatives containing nicotinamide unit were designed, synthesized and evaluated for their potential cytotoxic activities against human cancer cell lines. All the synthesized compounds were characterized using spectroscopic methods mainly including (1)H NMR, (13)C NMR and MS. The bio-evaluation results indicated that some of the obtained compounds (such as 4d, 4h, 4i) exhibited good to moderate cytotoxic effects on lung cancer cell lines (NCI-H460, A549, and NCI-H1975), especially, compound 4d exhibited the highly potential inhibitory activities against NCI-H460 cell line with the IC(50) values of 4.07 ± 1.30 μg/mL, which might be developed as novel lead compounds for potential cytotoxic agents. Springer International Publishing 2017-10-24 /pmc/articles/PMC5655388/ /pubmed/29086880 http://dx.doi.org/10.1186/s13065-017-0338-5 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Peng, Min
Shi, Liqiao
Ke, Shaoyong
Nicotinamide-based diamides derivatives as potential cytotoxic agents: synthesis and biological evaluation
title Nicotinamide-based diamides derivatives as potential cytotoxic agents: synthesis and biological evaluation
title_full Nicotinamide-based diamides derivatives as potential cytotoxic agents: synthesis and biological evaluation
title_fullStr Nicotinamide-based diamides derivatives as potential cytotoxic agents: synthesis and biological evaluation
title_full_unstemmed Nicotinamide-based diamides derivatives as potential cytotoxic agents: synthesis and biological evaluation
title_short Nicotinamide-based diamides derivatives as potential cytotoxic agents: synthesis and biological evaluation
title_sort nicotinamide-based diamides derivatives as potential cytotoxic agents: synthesis and biological evaluation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655388/
https://www.ncbi.nlm.nih.gov/pubmed/29086880
http://dx.doi.org/10.1186/s13065-017-0338-5
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AT shiliqiao nicotinamidebaseddiamidesderivativesaspotentialcytotoxicagentssynthesisandbiologicalevaluation
AT keshaoyong nicotinamidebaseddiamidesderivativesaspotentialcytotoxicagentssynthesisandbiologicalevaluation

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