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In situ fibrillizing amyloid-beta 1-42 induces neurite degeneration and apoptosis of differentiated SH-SY5Y cells

The progression of Alzheimer’s disease is causatively linked to the accumulation of amyloid-β aggregates in the brain, however, it is not clear how the amyloid aggregates initiate the death of neuronal cells. The in vitro toxic effects of amyloid peptides are most commonly examined using the human n...

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Detalles Bibliográficos
Autores principales: Krishtal, Jekaterina, Bragina, Olga, Metsla, Kristel, Palumaa, Peep, Tõugu, Vello
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655426/
https://www.ncbi.nlm.nih.gov/pubmed/29065138
http://dx.doi.org/10.1371/journal.pone.0186636