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Negatively charged residues in the first extracellular loop of the L-type Ca(V)1.2 channel anchor the interaction with the Ca(V)α2δ1 auxiliary subunit
Voltage-gated L-type Ca(V)1.2 channels in cardiomyocytes exist as heteromeric complexes. Co-expression of Ca(V)α2δ1 with Ca(V)β/Ca(V)α1 proteins reconstitutes the functional properties of native L-type currents, but the interacting domains at the Ca(V)1.2/Ca(V)α2δ1 interface are unknown. Here, a hom...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655503/ https://www.ncbi.nlm.nih.gov/pubmed/28864774 http://dx.doi.org/10.1074/jbc.M117.806893 |