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Negatively charged residues in the first extracellular loop of the L-type Ca(V)1.2 channel anchor the interaction with the Ca(V)α2δ1 auxiliary subunit

Voltage-gated L-type Ca(V)1.2 channels in cardiomyocytes exist as heteromeric complexes. Co-expression of Ca(V)α2δ1 with Ca(V)β/Ca(V)α1 proteins reconstitutes the functional properties of native L-type currents, but the interacting domains at the Ca(V)1.2/Ca(V)α2δ1 interface are unknown. Here, a hom...

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Detalles Bibliográficos
Autores principales:	Bourdin, Benoîte, Briot, Julie, Tétreault, Marie-Philippe, Sauvé, Rémy, Parent, Lucie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2017
Materias:	Membrane Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655503/ https://www.ncbi.nlm.nih.gov/pubmed/28864774 http://dx.doi.org/10.1074/jbc.M117.806893

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