Uptake of glucose-conjugated MGMT inhibitors in cancer cells: role of flippases and type IV P-type ATPases

The DNA repair protein O (6)-methylguanine-DNA-methyltransferase (MGMT) is a key determinant of cancer resistance. The MGMT inhibitors O (6)-benzylguanine (O(6)BG) and O (6)-(4-bromothenyl)guanine (O(6)BTG) failed to enhance the therapeutic response due to toxic side effects when applied in combinat...

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Detalles Bibliográficos
Autores principales: Tomaszowski, Karl-Heinz, Hellmann, Nadja, Ponath, Viviane, Takatsu, Hiroyuki, Shin, Hye-Won, Kaina, Bernd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655675/
https://www.ncbi.nlm.nih.gov/pubmed/29066805
http://dx.doi.org/10.1038/s41598-017-14129-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655675/
https://www.ncbi.nlm.nih.gov/pubmed/29066805
http://dx.doi.org/10.1038/s41598-017-14129-x

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