Conformational stabilization as a strategy to prevent nucleophosmin mislocalization in leukemia

Nucleophosmin (NPM) is a nucleolar protein involved in ribosome assembly and cell homeostasis. Mutations in the C-terminal domain of NPM that impair native folding and localization are associated with acute myeloid leukemia (AML). We have performed a high-throughput screening searching for compounds...

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Detalles Bibliográficos
Autores principales: Urbaneja, María A., Skjærven, Lars, Aubi, Oscar, Underhaug, Jarl, López, David J., Arregi, Igor, Alonso-Mariño, Marián, Cuevas, Andoni, Rodríguez, José A., Martinez, Aurora, Bañuelos, Sonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655693/
https://www.ncbi.nlm.nih.gov/pubmed/29066752
http://dx.doi.org/10.1038/s41598-017-14497-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655693/
https://www.ncbi.nlm.nih.gov/pubmed/29066752
http://dx.doi.org/10.1038/s41598-017-14497-4

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