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Another piece in the progranulin puzzle: special binding between progranulin and prosaposin creates additional lysosomal access: An Editorial Comment for ‘The interaction between progranulin and prosaposin is mediated by granulins and the linker region between saposin B and C’ on page 236
Loss‐of‐function mutations in the gene encoding the growth factor progranulin cause degeneration of the ageing brain in a dose‐dependent manner. While heterozygous mutations result in adult onset frontotemporal dementia, the much rarer homozygous null mutations cause an early onset lysosomal storage...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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John Wiley and Sons Inc.
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655790/ https://www.ncbi.nlm.nih.gov/pubmed/28776681 http://dx.doi.org/10.1111/jnc.14125 |