Condensin II and GAIT complexes cooperate to restrict LINE-1 retrotransposition in epithelial cells

LINE-1 (L1) retrotransposons can mobilize (retrotranspose) within the human genome, and mutagenic de novo L1 insertions can lead to human diseases, including cancers. As a result, cells are actively engaged in preventing L1 retrotransposition. This work reveals that the human Condensin II complex re...

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Detalles Bibliográficos
Autores principales: Ward, Jacqueline R., Vasu, Kommireddy, Deutschman, Emily, Halawani, Dalia, Larson, Peter A., Zhang, Dongmei, Willard, Belinda, Fox, Paul L., Moran, John V., Longworth, Michelle S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656329/
https://www.ncbi.nlm.nih.gov/pubmed/29028794
http://dx.doi.org/10.1371/journal.pgen.1007051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656329/
https://www.ncbi.nlm.nih.gov/pubmed/29028794
http://dx.doi.org/10.1371/journal.pgen.1007051

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