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Condensin II and GAIT complexes cooperate to restrict LINE-1 retrotransposition in epithelial cells
LINE-1 (L1) retrotransposons can mobilize (retrotranspose) within the human genome, and mutagenic de novo L1 insertions can lead to human diseases, including cancers. As a result, cells are actively engaged in preventing L1 retrotransposition. This work reveals that the human Condensin II complex re...
Autores principales: | Ward, Jacqueline R., Vasu, Kommireddy, Deutschman, Emily, Halawani, Dalia, Larson, Peter A., Zhang, Dongmei, Willard, Belinda, Fox, Paul L., Moran, John V., Longworth, Michelle S. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656329/ https://www.ncbi.nlm.nih.gov/pubmed/29028794 http://dx.doi.org/10.1371/journal.pgen.1007051 |
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