A drug pocket at the lipid bilayer–potassium channel interface

Many pharmaceutical drugs against neurological and cardiovascular disorders exert their therapeutic effects by binding to specific sites on voltage-gated ion channels of neurons or cardiomyocytes. To date, all molecules targeting known ion channel sites bind to protein pockets that are mainly surrou...

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Detalles Bibliográficos
Autores principales: Ottosson, Nina E., Silverå Ejneby, Malin, Wu, Xiongyu, Yazdi, Samira, Konradsson, Peter, Lindahl, Erik, Elinder, Fredrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656419/
https://www.ncbi.nlm.nih.gov/pubmed/29075666
http://dx.doi.org/10.1126/sciadv.1701099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656419/
https://www.ncbi.nlm.nih.gov/pubmed/29075666
http://dx.doi.org/10.1126/sciadv.1701099

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