Inhibition of DYRK1A disrupts neural lineage specificationin human pluripotent stem cells

Genetic analysis has revealed that the dual specificity protein kinase DYRK1A has multiple roles in the development of the central nervous system. Increased DYRK1A gene dosage, such as occurs in Down syndrome, is known to affect neural progenitor cell differentiation, while haploinsufficiency of DYR...

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Detalles Bibliográficos
Autores principales: Bellmaine, Stephanie F, Ovchinnikov, Dmitry A, Manallack, David T, Cuddy, Claire E, Elefanty, Andrew G, Stanley, Edouard G, Wolvetang, Ernst J, Williams, Spencer J, Pera, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Stem Cells and Regenerative Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656431/
https://www.ncbi.nlm.nih.gov/pubmed/28884684
http://dx.doi.org/10.7554/eLife.24502

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656431/
https://www.ncbi.nlm.nih.gov/pubmed/28884684
http://dx.doi.org/10.7554/eLife.24502

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