Probing Resistance Mutations in Retroviral Integrases by Direct Measurement of Dolutegravir Fluorescence

FDA-approved integrase strand transfer inhibitors (raltegravir, elvitegravir and dolutegravir) efficiently inhibit HIV-1 replication. Here, we present fluorescence properties of these inhibitors. Dolutegravir displays an excitation mode particularly dependent on Mg(2+) chelation, allowing to directl...

Descripción completa

Detalles Bibliográficos
Autores principales: Thierry, Eloïse, Lebourgeois, Samuel, Simon, Françoise, Delelis, Olivier, Deprez, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656594/
https://www.ncbi.nlm.nih.gov/pubmed/29070877
http://dx.doi.org/10.1038/s41598-017-14564-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656594/
https://www.ncbi.nlm.nih.gov/pubmed/29070877
http://dx.doi.org/10.1038/s41598-017-14564-w

Ejemplares similares