Effects of Ketoconazole on the Pharmacokinetics of Mifepristone, a Competitive Glucocorticoid Receptor Antagonist, in Healthy Men

INTRODUCTION: Mifepristone, a competitive glucocorticoid receptor antagonist approved for Cushing syndrome, and ketoconazole, an antifungal and steroidogenesis inhibitor, are both inhibitors of and substrates for cytochrome P450 (CYP3A4). This study evaluated the pharmacokinetic effects of concomita...

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Detalles Bibliográficos
Autores principales: Nguyen, Dat, Mizne, Sarah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656713/
https://www.ncbi.nlm.nih.gov/pubmed/29022184
http://dx.doi.org/10.1007/s12325-017-0621-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656713/
https://www.ncbi.nlm.nih.gov/pubmed/29022184
http://dx.doi.org/10.1007/s12325-017-0621-9

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