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Escaping Host Factor PI4KB Inhibition: Enterovirus Genomic RNA Replication in the Absence of Replication Organelles

Enteroviruses reorganize cellular endomembranes into replication organelles (ROs) for genome replication. Although enterovirus replication depends on phosphatidylinositol 4-kinase type IIIβ (PI4KB), its role, and that of its product, phosphatidylinositol 4-phosphate (PI4P), is only partially underst...

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Detalles Bibliográficos
Autores principales: Melia, Charlotte E., van der Schaar, Hilde M., Lyoo, Heyrhyoung, Limpens, Ronald W.A.L., Feng, Qian, Wahedi, Maryam, Overheul, Gijs J., van Rij, Ronald P., Snijder, Eric J., Koster, Abraham J., Bárcena, Montserrat, van Kuppeveld, Frank J.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656745/
https://www.ncbi.nlm.nih.gov/pubmed/29045829
http://dx.doi.org/10.1016/j.celrep.2017.09.068