USP7 Is a Tumor-Specific WNT Activator for APC-Mutated Colorectal Cancer by Mediating β-Catenin Deubiquitination

The tumor suppressor gene adenomatous polyposis coli (APC) is mutated in most colorectal cancers (CRCs), resulting in constitutive Wnt activation. To understand the Wnt-activating mechanism of the APC mutation, we applied CRISPR/Cas9 technology to engineer various APC-truncated isogenic lines. We fi...

Descripción completa

Detalles Bibliográficos
Autores principales: Novellasdemunt, Laura, Foglizzo, Valentina, Cuadrado, Laura, Antas, Pedro, Kucharska, Anna, Encheva, Vesela, Snijders, Ambrosius P., Li, Vivian S.W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656747/
https://www.ncbi.nlm.nih.gov/pubmed/29045831
http://dx.doi.org/10.1016/j.celrep.2017.09.072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656747/
https://www.ncbi.nlm.nih.gov/pubmed/29045831
http://dx.doi.org/10.1016/j.celrep.2017.09.072

Ejemplares similares