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Boronic acids facilitate rapid oxime condensations at neutral pH

We report here the discovery and development of boron-assisted oxime formation as a powerful connective reaction for chemical biology. Oximes proximal to boronic acids form in neutral aqueous buffer with rate constants of more than 10(4) M(–1) s(–1), the largest to date for any oxime condensation. B...

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Detalles Bibliográficos
Autores principales: Schmidt, Pascal, Stress, Cedric, Gillingham, Dennis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656983/
https://www.ncbi.nlm.nih.gov/pubmed/29142692
http://dx.doi.org/10.1039/c5sc00921a