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Boronic acids facilitate rapid oxime condensations at neutral pH
We report here the discovery and development of boron-assisted oxime formation as a powerful connective reaction for chemical biology. Oximes proximal to boronic acids form in neutral aqueous buffer with rate constants of more than 10(4) M(–1) s(–1), the largest to date for any oxime condensation. B...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656983/ https://www.ncbi.nlm.nih.gov/pubmed/29142692 http://dx.doi.org/10.1039/c5sc00921a |