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The γ (c) family of cytokines: fine-tuning signals from IL-2 and IL-21 in the regulation of the immune response

Interleukin (IL)-2, IL-4, IL-7, IL-9, IL-15, and IL-21 form a family of cytokines based on the sharing of a receptor component, the common cytokine receptor γ chain, γ (c), which is encoded by the gene mutated in humans with X-linked severe combined immunodeficiency (XSCID). Together, these cytokine...

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Detalles Bibliográficos
Autores principales: Spolski, Rosanne, Gromer, Daniel, Leonard, Warren J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657018/
https://www.ncbi.nlm.nih.gov/pubmed/29123649
http://dx.doi.org/10.12688/f1000research.12202.1
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author Spolski, Rosanne
Gromer, Daniel
Leonard, Warren J.
author_facet Spolski, Rosanne
Gromer, Daniel
Leonard, Warren J.
author_sort Spolski, Rosanne
collection PubMed
description Interleukin (IL)-2, IL-4, IL-7, IL-9, IL-15, and IL-21 form a family of cytokines based on the sharing of a receptor component, the common cytokine receptor γ chain, γ (c), which is encoded by the gene mutated in humans with X-linked severe combined immunodeficiency (XSCID). Together, these cytokines play critical roles in lymphoid development, differentiation, growth, and survival as well as mediating effector function. Here, we provide an overview of the main actions of members of this cytokine family but then primarily focus on IL-2 and IL-21, discussing their dynamic interplay and contributions to a fine-tuned immune response. Moreover, we discuss the therapeutic utility of modulating their actions, particularly for autoimmunity and cancer.
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spelling pubmed-56570182017-11-08 The γ (c) family of cytokines: fine-tuning signals from IL-2 and IL-21 in the regulation of the immune response Spolski, Rosanne Gromer, Daniel Leonard, Warren J. F1000Res Review Interleukin (IL)-2, IL-4, IL-7, IL-9, IL-15, and IL-21 form a family of cytokines based on the sharing of a receptor component, the common cytokine receptor γ chain, γ (c), which is encoded by the gene mutated in humans with X-linked severe combined immunodeficiency (XSCID). Together, these cytokines play critical roles in lymphoid development, differentiation, growth, and survival as well as mediating effector function. Here, we provide an overview of the main actions of members of this cytokine family but then primarily focus on IL-2 and IL-21, discussing their dynamic interplay and contributions to a fine-tuned immune response. Moreover, we discuss the therapeutic utility of modulating their actions, particularly for autoimmunity and cancer. F1000Research 2017-10-23 /pmc/articles/PMC5657018/ /pubmed/29123649 http://dx.doi.org/10.12688/f1000research.12202.1 Text en Copyright: © 2017 Spolski R et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The author(s) is/are employees of the US Government and therefore domestic copyright protection in USA does not apply to this work. The work may be protected under the copyright laws of other jurisdictions when used in those jurisdictions.
spellingShingle Review
Spolski, Rosanne
Gromer, Daniel
Leonard, Warren J.
The γ (c) family of cytokines: fine-tuning signals from IL-2 and IL-21 in the regulation of the immune response
title The γ (c) family of cytokines: fine-tuning signals from IL-2 and IL-21 in the regulation of the immune response
title_full The γ (c) family of cytokines: fine-tuning signals from IL-2 and IL-21 in the regulation of the immune response
title_fullStr The γ (c) family of cytokines: fine-tuning signals from IL-2 and IL-21 in the regulation of the immune response
title_full_unstemmed The γ (c) family of cytokines: fine-tuning signals from IL-2 and IL-21 in the regulation of the immune response
title_short The γ (c) family of cytokines: fine-tuning signals from IL-2 and IL-21 in the regulation of the immune response
title_sort the γ (c) family of cytokines: fine-tuning signals from il-2 and il-21 in the regulation of the immune response
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657018/
https://www.ncbi.nlm.nih.gov/pubmed/29123649
http://dx.doi.org/10.12688/f1000research.12202.1
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