A framework for the design, conduct and interpretation of randomised controlled trials in the presence of treatment changes

BACKGROUND: When a randomised trial is subject to deviations from randomised treatment, analysis according to intention-to-treat does not estimate two important quantities: relative treatment efficacy and effectiveness in a setting different from that in the trial. Even in trials of a predominantly...

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Detalles Bibliográficos
Autores principales: Dodd, Susanna, White, Ian R., Williamson, Paula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657109/
https://www.ncbi.nlm.nih.gov/pubmed/29070048
http://dx.doi.org/10.1186/s13063-017-2240-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657109/
https://www.ncbi.nlm.nih.gov/pubmed/29070048
http://dx.doi.org/10.1186/s13063-017-2240-9

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