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A framework for the design, conduct and interpretation of randomised controlled trials in the presence of treatment changes
BACKGROUND: When a randomised trial is subject to deviations from randomised treatment, analysis according to intention-to-treat does not estimate two important quantities: relative treatment efficacy and effectiveness in a setting different from that in the trial. Even in trials of a predominantly...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657109/ https://www.ncbi.nlm.nih.gov/pubmed/29070048 http://dx.doi.org/10.1186/s13063-017-2240-9 |