Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumor suppressor

Direct interactions between pro- and anti-apoptotic BCL-2 family members form the basis of cell death decision-making at the outer mitochondrial membrane (OMM). Here we report that three antiapoptotic BCL-2 proteins (MCL-1, BCL-2, and BCL-XL) found untethered from the OMM function as transcriptional...

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Detalles Bibliográficos
Autores principales: Wu, Xiaofeng, Zhang, Li-shu, Toombs, Jason, Kuo, Yi-Chun, Piazza, John Tyler, Tuladhar, Rubina, Barrett, Quinn, Fan, Chih-wei, Zhang, Xuewu, Walensky, Loren D., Kool, Marcel, Cheng, Steven Y., Brekken, Rolf, Opferman, Joseph T., Green, Douglas R., Moldoveanu, Tudor, Lum, Lawrence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657599/
https://www.ncbi.nlm.nih.gov/pubmed/28945232
http://dx.doi.org/10.1038/ncb3616

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657599/
https://www.ncbi.nlm.nih.gov/pubmed/28945232
http://dx.doi.org/10.1038/ncb3616

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