Systemic Gene Delivery Transduces the Enteric Nervous System of Guinea Pigs and Cynomolgus Macaques

Characterization of adeno-associated viral vector (AAV) mediated gene delivery to the enteric nervous system (ENS) was recently described in mice and rats. In these proof-of-concept experiments, we show that intravenous injections of clinically relevant AAVs can transduce the ENS in guinea pigs and...

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Detalles Bibliográficos
Autores principales: Gombash, Sara E, Cowley, Christopher J, Fitzgerald, Julie A, Lepak, Christina A, Neides, Mitchell G, Hook, Kathryn, Todd, Levi J, Wang, Guo-Du, Mueller, Christian, Kaspar, Brian K, Bielefeld, Eric C, Fischer, Andrew J, Wood, Jackie D, Foust, Kevin D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658254/
https://www.ncbi.nlm.nih.gov/pubmed/28771235
http://dx.doi.org/10.1038/gt.2017.72

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658254/
https://www.ncbi.nlm.nih.gov/pubmed/28771235
http://dx.doi.org/10.1038/gt.2017.72

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