Population Exposure‐Response Modeling Supported Selection of Naloxegol Doses in Phase III Studies in Patients With Opioid‐Induced Constipation

Naloxegol is approved for the treatment of opioid‐induced constipation (OIC) in adults with chronic noncancer pain. Population exposure‐response models were developed using data from a phase II study comprising 185 adults with OIC. The weekly probability of response defined as having ≥3/week spontan...

Descripción completa

Detalles Bibliográficos
Autores principales: Al‐Huniti, Nidal, Xu, Hongmei, Zhou, Diansong, Aksenov, Sergey, Fox, Robert, Bui, Khanh H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658281/
https://www.ncbi.nlm.nih.gov/pubmed/28782266
http://dx.doi.org/10.1002/psp4.12229

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658281/
https://www.ncbi.nlm.nih.gov/pubmed/28782266
http://dx.doi.org/10.1002/psp4.12229

Ejemplares similares