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A Translational Systems Pharmacology Model for Aβ Kinetics in Mouse, Monkey, and Human

A mechanistic model of amyloid beta production, degradation, and distribution was constructed for mouse, monkey, and human, calibrated and externally verified across multiple datasets. Simulations of single‐dose avagacestat treatment demonstrate that the Aβ(42) brain inhibition may exceed that in ce...

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Detalles Bibliográficos
Autores principales: Karelina, T, Demin, O, Nicholas, T, Lu, Y, Duvvuri, S, Barton, HA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658289/
https://www.ncbi.nlm.nih.gov/pubmed/28571112
http://dx.doi.org/10.1002/psp4.12211