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A Translational Systems Pharmacology Model for Aβ Kinetics in Mouse, Monkey, and Human
A mechanistic model of amyloid beta production, degradation, and distribution was constructed for mouse, monkey, and human, calibrated and externally verified across multiple datasets. Simulations of single‐dose avagacestat treatment demonstrate that the Aβ(42) brain inhibition may exceed that in ce...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658289/ https://www.ncbi.nlm.nih.gov/pubmed/28571112 http://dx.doi.org/10.1002/psp4.12211 |