Neurofilament light protein in CSF and blood is associated with neurodegeneration and disease severity in Huntington’s disease R6/2 mice

There is an unmet need to reliably and non-invasively monitor disease progression in preclinical Huntington’s disease (HD) models. As a marker of axonal damage, neurofilament light chain (NfL) has been suggested a marker for neurodegeneration. NfL concentrations in blood and CSF were recently shown...

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Detalles Bibliográficos
Autores principales: Soylu-Kucharz, Rana, Sandelius, Åsa, Sjögren, Marie, Blennow, Kaj, Wild, Edward J., Zetterberg, Henrik, Björkqvist, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658344/
https://www.ncbi.nlm.nih.gov/pubmed/29074982
http://dx.doi.org/10.1038/s41598-017-14179-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658344/
https://www.ncbi.nlm.nih.gov/pubmed/29074982
http://dx.doi.org/10.1038/s41598-017-14179-1

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