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Limiting habenular hyperactivity ameliorates maternal separation-driven depressive-like symptoms
Early-life stress, including maternal separation (MS), increases the vulnerability to develop mood disorders later in life, but the underlying mechanisms remain elusive. We report that MS promotes depressive-like symptoms in mice at a mature stage of life. Along with this behavioral phenotype, MS dr...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658350/ https://www.ncbi.nlm.nih.gov/pubmed/29074844 http://dx.doi.org/10.1038/s41467-017-01192-1 |
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author | Tchenio, Anna Lecca, Salvatore Valentinova, Kristina Mameli, Manuel |
author_facet | Tchenio, Anna Lecca, Salvatore Valentinova, Kristina Mameli, Manuel |
author_sort | Tchenio, Anna |
collection | PubMed |
description | Early-life stress, including maternal separation (MS), increases the vulnerability to develop mood disorders later in life, but the underlying mechanisms remain elusive. We report that MS promotes depressive-like symptoms in mice at a mature stage of life. Along with this behavioral phenotype, MS drives reduction of GABA(B)-GIRK signaling and the subsequent lateral habenula (LHb) hyperexcitability—an anatomical substrate devoted to aversive encoding. Attenuating LHb hyperactivity using chemogenetic tools and deep-brain stimulation ameliorates MS depressive-like symptoms. This provides insights on mechanisms and strategies to alleviate stress-dependent affective behaviors. |
format | Online Article Text |
id | pubmed-5658350 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-56583502017-10-30 Limiting habenular hyperactivity ameliorates maternal separation-driven depressive-like symptoms Tchenio, Anna Lecca, Salvatore Valentinova, Kristina Mameli, Manuel Nat Commun Article Early-life stress, including maternal separation (MS), increases the vulnerability to develop mood disorders later in life, but the underlying mechanisms remain elusive. We report that MS promotes depressive-like symptoms in mice at a mature stage of life. Along with this behavioral phenotype, MS drives reduction of GABA(B)-GIRK signaling and the subsequent lateral habenula (LHb) hyperexcitability—an anatomical substrate devoted to aversive encoding. Attenuating LHb hyperactivity using chemogenetic tools and deep-brain stimulation ameliorates MS depressive-like symptoms. This provides insights on mechanisms and strategies to alleviate stress-dependent affective behaviors. Nature Publishing Group UK 2017-10-26 /pmc/articles/PMC5658350/ /pubmed/29074844 http://dx.doi.org/10.1038/s41467-017-01192-1 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Tchenio, Anna Lecca, Salvatore Valentinova, Kristina Mameli, Manuel Limiting habenular hyperactivity ameliorates maternal separation-driven depressive-like symptoms |
title | Limiting habenular hyperactivity ameliorates maternal separation-driven depressive-like symptoms |
title_full | Limiting habenular hyperactivity ameliorates maternal separation-driven depressive-like symptoms |
title_fullStr | Limiting habenular hyperactivity ameliorates maternal separation-driven depressive-like symptoms |
title_full_unstemmed | Limiting habenular hyperactivity ameliorates maternal separation-driven depressive-like symptoms |
title_short | Limiting habenular hyperactivity ameliorates maternal separation-driven depressive-like symptoms |
title_sort | limiting habenular hyperactivity ameliorates maternal separation-driven depressive-like symptoms |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658350/ https://www.ncbi.nlm.nih.gov/pubmed/29074844 http://dx.doi.org/10.1038/s41467-017-01192-1 |
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