A guanidine-appended scyllo-inositol derivative AAD-66 enhances brain delivery and ameliorates Alzheimer’s phenotypes

Alzheimer’s disease (AD) is a degenerative brain disease that destroys memory and other important mental functions but lacks efficient therapeutic agents. Blocking toxic amyloid β (Aβ) could be beneficial for AD and represents a promising therapeutic strategy for AD treatment. scyllo-Inositol (SI) i...

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Detalles Bibliográficos
Autores principales: Lee, Dohyun, Lee, Woo-Sirl, Lim, Sungsu, Kim, Yun Kyung, Jung, Hoe-Yune, Das, Sanket, Lee, Juhyun, Luo, Wenjie, Kim, Kyong-Tai, Chung, Sung-Kee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658413/
https://www.ncbi.nlm.nih.gov/pubmed/29074878
http://dx.doi.org/10.1038/s41598-017-14559-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658413/
https://www.ncbi.nlm.nih.gov/pubmed/29074878
http://dx.doi.org/10.1038/s41598-017-14559-7

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