Can Matching-Adjusted Indirect Comparison Methods Mitigate Placebo Response Differences Among Patient Populations in Adjunctive Trials of Brivaracetam and Levetiracetam?

BACKGROUND AND OBJECTIVE: Patients with focal seizures recruited into adjunctive antiepileptic drug (AED) trials have become more refractory and severe over time; concurrently, placebo responses have increased. To attempt to account for heterogeneity among trials, propensity-score weighted patient-l...

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Detalles Bibliográficos
Autores principales: Swallow, Elyse, Fang, Anna, Signorovitch, James, Plumb, Jonathan, Borghs, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2017
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658476/
https://www.ncbi.nlm.nih.gov/pubmed/28856580
http://dx.doi.org/10.1007/s40263-017-0462-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658476/
https://www.ncbi.nlm.nih.gov/pubmed/28856580
http://dx.doi.org/10.1007/s40263-017-0462-8

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