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Can Matching-Adjusted Indirect Comparison Methods Mitigate Placebo Response Differences Among Patient Populations in Adjunctive Trials of Brivaracetam and Levetiracetam?
BACKGROUND AND OBJECTIVE: Patients with focal seizures recruited into adjunctive antiepileptic drug (AED) trials have become more refractory and severe over time; concurrently, placebo responses have increased. To attempt to account for heterogeneity among trials, propensity-score weighted patient-l...
Autores principales: | Swallow, Elyse, Fang, Anna, Signorovitch, James, Plumb, Jonathan, Borghs, Simon |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658476/ https://www.ncbi.nlm.nih.gov/pubmed/28856580 http://dx.doi.org/10.1007/s40263-017-0462-8 |
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