Distinct Cell-Cycle Control in Two Different States of Mouse Pluripotency

Mouse embryonic stem cells (ESCs) cultured in serum are characterized by hyper-phosphorylated RB protein, lack of G1 control, and rapid progression through the cell cycle. Here, we show that ESCs grown in the presence of two small-molecule inhibitors (2i ESCs) have a longer G1-phase with hypo-phosph...

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Detalles Bibliográficos
Autores principales: ter Huurne, Menno, Chappell, James, Dalton, Stephen, Stunnenberg, Hendrik G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658514/
https://www.ncbi.nlm.nih.gov/pubmed/28985526
http://dx.doi.org/10.1016/j.stem.2017.09.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658514/
https://www.ncbi.nlm.nih.gov/pubmed/28985526
http://dx.doi.org/10.1016/j.stem.2017.09.004

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