Genome-wide loss-of-function genetic screening identifies opioid receptor μ1 as a key regulator of L-asparaginase resistance in pediatric acute lymphoblastic leukemia

L-asparaginase is a critical chemotherapeutic agent for acute lymphoblastic leukemia (ALL). It hydrolyzes plasma asparagine into aspartate and NH(3), causing asparagine deficit and inhibition of protein synthesis and eventually, leukemic cell death. However, patient relapse often occurs due to devel...

Descripción completa

Detalles Bibliográficos
Autores principales: Kang, S M, Rosales, J L, Meier-Stephenson, V, Kim, S, Lee, K Y, Narendran, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658664/
https://www.ncbi.nlm.nih.gov/pubmed/28650467
http://dx.doi.org/10.1038/onc.2017.211

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658664/
https://www.ncbi.nlm.nih.gov/pubmed/28650467
http://dx.doi.org/10.1038/onc.2017.211

Ejemplares similares