De novo MYC addiction as an adaptive response of cancer cells to CDK4/6 inhibition

Cyclin‐dependent kinases (CDK) are rational cancer therapeutic targets fraught with the development of acquired resistance by tumor cells. Through metabolic and transcriptomic analyses, we show that the inhibition of CDK4/6 leads to a metabolic reprogramming associated with gene networks orchestrate...

Descripción completa

Detalles Bibliográficos
Autores principales: Tarrado‐Castellarnau, Míriam, de Atauri, Pedro, Tarragó‐Celada, Josep, Perarnau, Jordi, Yuneva, Mariia, Thomson, Timothy M, Cascante, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658703/
https://www.ncbi.nlm.nih.gov/pubmed/28978620
http://dx.doi.org/10.15252/msb.20167321

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658703/
https://www.ncbi.nlm.nih.gov/pubmed/28978620
http://dx.doi.org/10.15252/msb.20167321

Ejemplares similares