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Detecting the tipping points in a three-state model of complex diseases by temporal differential networks
BACKGROUND: The progression of complex diseases, such as diabetes and cancer, is generally a nonlinear process with three stages, i.e., normal state, pre-disease state, and disease state, where the pre-disease state is a critical state or tipping point immediately preceding the disease state. Tradit...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658963/ https://www.ncbi.nlm.nih.gov/pubmed/29073904 http://dx.doi.org/10.1186/s12967-017-1320-7 |