Enzymatic and Chemoenzymatic Three‐Step Cascades for the Synthesis of Stereochemically Complementary Trisubstituted Tetrahydroisoquinolines

Chemoenzymatic and enzymatic cascade reactions enable the synthesis of complex stereocomplementary 1,3,4‐trisubstituted tetrahydroisoquinolines (THIQs) with three chiral centers in a step‐efficient and selective manner without intermediate purification. The cascade employs inexpensive substrates (3‐...

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Detalles Bibliográficos
Autores principales: Erdmann, Vanessa, Lichman, Benjamin R., Zhao, Jianxiong, Simon, Robert C., Kroutil, Wolfgang, Ward, John M., Hailes, Helen C., Rother, Dörte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658969/
https://www.ncbi.nlm.nih.gov/pubmed/28727894
http://dx.doi.org/10.1002/anie.201705855

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658969/
https://www.ncbi.nlm.nih.gov/pubmed/28727894
http://dx.doi.org/10.1002/anie.201705855

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